Nowadays, Potency (pharmacology) is a topic that has become increasingly relevant in today's society. With the advancement of technology and globalization, Potency (pharmacology) has become a fundamental aspect in people's daily lives. Whether on a personal, professional or social level, Potency (pharmacology) has left a significant mark on the way we interact with the world around us. In this article, we will explore different aspects related to Potency (pharmacology), from its impact on mental health to its influence on the global economy. We will also look at how Potency (pharmacology) has evolved over time and how it has affected various communities and cultures around the world. Through a multidisciplinary approach, we will seek to understand the importance and implications of Potency (pharmacology) in modern society.
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In pharmacology, potency or biological potency is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity. A highly potent drug (e.g., fentanyl, clonazepam, risperidone, benperidol, bumetanide) evokes a given response at low concentrations, while a drug of lower potency (e.g. morphine, alprazolam, ziprasidone, haloperidol, furosemide) evokes the same response only at higher concentrations. Higher potency does not necessarily mean greater effectiveness or more side effects.
The International Union of Basic and Clinical Pharmacology (IUPHAR) has stated that "potency is an imprecise term that should always be further defined", and lists of types of potency as follows:
Type of potency | Symbol | Definition |
---|---|---|
Effective dose | It is the minimum dose or concentration of a drug that produces a biological response in 50% of a population being studied. | |
Median lethal dose | For either drugs or toxins, it is a toxic unit that measures the minimum dose that causes death (lethal dose) in 50% of cases. | |
Median toxic dose | It is the minimum dose at which toxicity occurs in 50% of cases. | |
Half maximal effective concentration | It is a measure of the concentration of a drug, antibody or toxicant which induces a biological response halfway between the baseline and maximum after a specified exposure time. In other words, it can be defined as the concentration required to obtain a 50% effect. | |
Half maximal inhibitory concentration | It is a measure of the potency of a substance in inhibiting a specific biological or biochemical function. |
https://www.addictioncenter.com/news/2019/08/15-most-dangerous-drugs/ https://nida.nih.gov/research-topics/commonly-used-drugs-charts#top