IFNA4

In this article, the topic IFNA4 will be addressed from a broad and detailed perspective, with the aim of providing readers with a complete and enriching vision of this matter. Through a comprehensive and rigorous analysis, different aspects and approaches related to IFNA4 will be explored, in order to provide relevant and up-to-date information. The various implications and consequences that IFNA4 can have in different contexts will also be examined, as well as possible solutions or recommendations to address this issue effectively. With a critical and reflective perspective, this article aims to offer the reader solid and well-founded knowledge about IFNA4, thus promoting greater understanding and awareness about it.

Protein-coding gene in the species Homo sapiens

IFNA4
Identifiers
Aliases	IFNA4, IFN-alpha4a, INFA4, interferon, alpha 4, interferon alpha 4
External IDs	OMIM: 147564; MGI: 3649260; HomoloGene: 68536; GeneCards: IFNA4; OMA:IFNA4 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p21.3 Start 21,186,694 bp End 21,187,671 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 C4|4 Start 88,594,152 bp End 88,595,161 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in aorta thoracic aorta ascending aorta n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity type I interferon receptor binding protein binding cytokine receptor binding Cellular component extracellular region extracellular space Biological process defense response adaptive immune response response to exogenous dsRNA response to virus blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein natural killer cell activation involved in immune response B cell proliferation humoral immune response defense response to virus type I interferon signaling pathway B cell differentiation T cell activation involved in immune response cytokine-mediated signaling pathway innate immune response regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3441 230398 Ensembl ENSG00000236637 ENSMUSG00000078355 UniProt P05014 Q810G1 RefSeq (mRNA) NM_021068 NM_206867 RefSeq (protein) NP_066546 NP_996750 Location (UCSC) Chr 9: 21.19 – 21.19 Mb Chr 4: 88.59 – 88.6 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interferon alpha-4 is a protein that in humans is encoded by the IFNA4 gene.

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000236637 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000078355 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
6. ^ "Entrez Gene: IFNA4 interferon, alpha 4".

Further reading

• Mizoguchi J, Pitha PM, Raj NB (1985). "Efficient expression in Escherichia coli of two species of human interferon-alpha and their hybrid molecules". DNA. 4 (3): 221–32. doi:10.1089/dna.1985.4.221. PMID 3891272.
• Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.
• Linnane AW, Beilharz MW, McMullen GL, et al. (1984). "Nucleotide sequence and expression in E. coli of a human interferon-alpha gene selected from a genomic library using synthetic oligonucleotides". Biochem. Int. 8 (5): 725–32. PMID 6089830.
• Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
• Hussain M, Gill DS, Liao MJ (1997). "Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population". J. Interferon Cytokine Res. 17 (9): 559–66. doi:10.1089/jir.1997.17.559. PMID 9335434.
• Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329 (Pt 2): 295–302. doi:10.1042/bj3290295. PMC 1219044. PMID 9425112.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yokota S, Yokosawa N, Okabayashi T, et al. (2004). "Induction of Suppressor of Cytokine Signaling-3 by Herpes Simplex Virus Type 1 Contributes to Inhibition of the Interferon Signaling Pathway". J. Virol. 78 (12): 6282–6. doi:10.1128/JVI.78.12.6282-6286.2004. PMC 416529. PMID 15163721.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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